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apalutamide will minimize the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with prescription drugs that happen to be CYP3A4 substrates can lead to decreased exposure to those drugs.Modafinil blocks DAT and r